See risks & benefits. Learn about what ZOLOFT® (sertraline HCl) is and how it works in the treatment of depression. Take this medicine only as directed by your doctor, to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This medicine should come with a Medication Guide. See risks & benefits. Learn more about ZOLOFT® (sertraline HCl), a prescription treatment for depression. Sertraline is a medication that increases the amount of serotonin in your brain. Serotonin is a hormone that helps regulate your mood. It treats depression, anxiety, obsessive-compulsive disorder, post-traumatic stress disorder and premenstrual dysphoric disorder. What is this medication? Zoloft is an antidepressant used to treat major depression, obsessive-compulsive disorder, panic disorder, social anxiety, and post-traumatic stress disorder. Zoloft (Sertraline Hcl) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Sertraline (Zoloft) is an SSRI used to treat depression, anxiety, OCD, PTSD, and PMDD by increasing serotonin levels to improve mood and emotional balance. Sertraline, sold under the brand name Zoloft among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class [11] used to treat major depressive disorder, generalized anxiety disorder, social anxiety disorder, obsessive–compulsive disorder (OCD), panic disorder, and premenstrual dysphoric disorder. [12] Learn about sertraline (Zoloft) usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Find patient medical information for Sertraline (Zoloft) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings.